6. What are the main
theoretical models that try to
explain the formation of the
enzyme-substrate complex?

Gap-fill exercise

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There are two main models that explain
the formation of the
complex: the lock and key model and
the induced fit model.

In the and model the enzyme
has a region with specific spatial
conformation for the binding of the
substrate. In the fit model the
binding of the substrate induces a
change in the configuration of
the enzyme for the substrate to fit.